Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of Tau protein in resistance to paclitaxel

29 Jun 2011

Abstract excerpt

Resistance to taxanes, related to limited efficacy of systemic therapy in cancer patients, is multifactorial. Among mechanisms of resistance to taxanes, those related to microtubule-associated proteins (MAP), including protein Tau, are of great importance. Protein Tau (50-64 kD) binds to beta-tubulin in the same place as paclitaxel. In preclinical studies, low expression of Tau in cancer cells was associated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer Treatment and Pharmacology
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21713447
DOI: 10.1007/s00280-011-1696-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of Tau protein in resistance to paclitaxelPMID 21713447Read ↗

Microtubule Associated Protein (MAP)-Tau: A Novel Mediator of Paclitaxel Sensitivity In Vitro and In VivoSemantic proximity Read ↗

Emerging Evidences for an Implication of the Neurodegeneration-Associated Protein TAU in CancerSemantic proximity Read ↗

Novel Functions of the Neurodegenerative-Related Gene Tau in CancerSemantic proximity Read ↗

Evaluation of prognostic and predictive value of microtubule associated protein tau in two independent cohortsSemantic proximity Read ↗

Expression and Silencing of the Microtubule-Associated Protein Tau in Breast Cancer CellsSemantic proximity Read ↗

Tau Protein as Therapeutic Target for Cancer? Focus on GlioblastomaSemantic proximity Read ↗

Microtubule‐Binding Proteins as Promising Biomarkers of Paclitaxel Sensitivity in Cancer ChemotherapySemantic proximity Read ↗

Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistanceSemantic proximity Read ↗

Microtubules: A dynamic target in cancer therapySemantic proximity Read ↗

Cancer Cells Upregulate Tau to Gain Resistance to DNA Damaging AgentsSemantic proximity Read ↗

A review of research progress of antitumor drugs based on tubulin targetsSemantic proximity Read ↗

Mechanisms of Tubulin Binding Ligands to Target Cancer Cells: Updates on their Therapeutic Potential and Clinical TrialsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.