Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear expression of Y box binding-1 is important for resistance to chemotherapy including gemcitabine in TP53-mutated bladder cancer.

International journal of oncology - 1 Aug 2017

Yamashita Takahisa, Higashi Morihiro, Momose Shuji, Morozumi Makoto, Tamaru Jun-Ichi

Abstract excerpt

The development and acquisition of multiple drug resistance in cancer cells remain a major obstacle in the treatment of bladder cancer. Nuclear translocation of Y box binding-1 (YB-1), which is a member of a family of DNA-binding proteins that contain a cold shock domain, plays a significant role in the acquisition of drug resistance by upregulating expression of the multidrug resistance-1 (MDR-1) gene product,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Deoxycytidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple

Share to Gemcitabine

Share to HeLa Cells

Share to MCF-7 Cells

Share to Urinary Bladder Neoplasms

Share to Y-Box-Binding Protein 1

Source

Identifiers

PMID: 28714514
DOI: 10.3892/ijo.2017.4031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear expression of Y box binding-1 is important for resistance to chemotherapy including gemcitabine in TP53-mutated bladder cancer.PMID 28714514Read ↗

Hyperthermia-induced Nuclear Translocation of Transcription Factor YB-1 Leads to Enhanced Expression of Multidrug Resistance-related ABC TransportersSemantic proximity Read ↗

Cancer Cells Upregulate Tau to Gain Resistance to DNA Damaging AgentsSemantic proximity Read ↗

Inhibition of Y Box Binding Protein 1 Suppresses Cell Growth and Motility in Colorectal CancerSemantic proximity Read ↗

Y box-binding protein-1 binds preferentially to single-stranded nucleic acids and exhibits 3'-->5' exonuclease activity.Semantic proximity Read ↗

YB-1 as a cell cycle-regulated transcription factor facilitating cyclin A and cyclin B1 gene expression.Semantic proximity Read ↗

Y-box protein-associated acidic protein (YBAP1/C1QBP) affects the localization and cytoplasmic functions of YB-1.Semantic proximity Read ↗

Direct Involvement of the Y-box Binding Protein YB-1 in Genotoxic Stress-induced Activation of the Human Multidrug Resistance 1 GeneSemantic proximity Read ↗

P300/CBP‐associated factor regulates Y‐box binding protein‐1 expression and promotes cancer cell growth, cancer invasion and drug resistanceSemantic proximity Read ↗

Y-box factor YB-1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor biologic factors HER2, uPA and PAI-1.Semantic proximity Read ↗

Targeted disruption of one allele of the Y-box binding protein-1 (YB-1) gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin C.Semantic proximity Read ↗

YB-1 represses AP1-dependent gene transactivation and interacts with an AP-1 DNA sequence.Semantic proximity Read ↗

Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.