Article
Haplotype Structures and Protein Levels of TGFB1 in HPV Infection and Cervical Lesion: A Case-Control Study.
Cells - 25 Dec 2022
Trugilo Kleber Paiva, Cebinelli Guilherme Cesar Martelossi, Pereira Érica Romão, Okuyama Nádia Calvo Martins, Cezar-Dos-Santos Fernando, Castilha Eliza Pizarro, Flauzino Tamires, Hoch Valéria Bumiller-Bini, Watanabe Maria Angelica Ehara, Guembarovski Roberta Losi, de Oliveira Karen Brajão
Abstract excerpt
This study aimed to verify the role of TGFB1 variants (c.-1638G>A, c.-1347C>T, c.29C>T, and c.74G>C) in HPV infection susceptibility and cervical lesions development, and their impact on TGFB1 cervical and plasma levels. TGFB1 genotypes were assessed with PCR-RFLP and haplotypes were inferred for 190 HPV-uninfected and 161 HPV-infected women. TGFB1 levels were determined with immunofluorimetric assay....
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