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Article

Transforming growth factor beta 1 (TGFβ1) polymorphisms and haplotype structures have dual roles in breast cancer pathogenesis.

Journal of cancer research and clinical oncology - 1 Apr 2018

Vitiello Glauco Akelinghton Freire, Guembarovski Roberta Losi, Hirata Bruna Karina Banin, Amarante Marla Karine, de Oliveira Carlos Eduardo Coral, de Oliveira Karen Brajão, Cebinelli Guilherme Cesar Martelossi, Guembarovski Alda Losi, Campos Clodoaldo Zago, Watanabe Maria Angelica Ehara

Abstract excerpt

PURPOSE: Despite the documented dual role of TGFβ1 in breast cancer (BC) pathogenesis, the subtype-specific influences of its polymorphisms remain undocumented. The present study investigated the effects of the TGFB1 promoter region (rs1800468 or G-800A and rs1800469 or C-509T) and signal peptide (rs1800470 or C29T and rs1800471 or G74C) single nucleotide polymorphisms (SNPs) and their haplotype structures on the...

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Share to Aged, 80 and over
Share to Breast Neoplasms
Share to Case-Control Studies
Share to Haplotypes
Share to Immunohistochemistry
Share to Polymorphism, Restriction Fragment Length
Share to Promoter Regions, Genetic
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Source

Identifiers

PMID: 29362917
DOI: 10.1007/s00432-018-2585-9

Genes

TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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