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Article

TGFβ receptor 1: an immune susceptibility gene in HPV-associated cancer.

Cancer research - 1 Dec 2014

Levovitz Chaya, Chen Dan, Ivansson Emma, Gyllensten Ulf, Finnigan John P, Alshawish Sara, Zhang Weijia, Schadt Eric E, Posner Marshal R, Genden Eric M, Boffetta Paolo, Sikora Andrew G

Abstract excerpt

Only a minority of those exposed to human papillomavirus (HPV) develop HPV-related cervical and oropharyngeal cancer. Because host immunity affects infection and progression to cancer, we tested the hypothesis that genetic variation in immune-related genes is a determinant of susceptibility to oropharyngeal cancer and other HPV-associated cancers by performing a multitier integrative computational analysis with...

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Identifiers

PMID: 25273091
DOI: 10.1158/0008-5472.CAN-14-0602-T
PMCID: PMC4496416

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