Article
Polymorphisms in the TGFB1 signal peptide influence human papillomavirus infection and development of cervical lesions.
Medical microbiology and immunology - 1 Feb 2019
Trugilo Kleber Paiva, Cebinelli Guilherme Cesar Martelossi, Berti Fernanda Costa Brandão, Okuyama Nádia Calvo Martins, Cezar-Dos-Santos Fernando, Sena Michelle Mota, Mangieri Luis Fernando Lásaro, Watanabe Maria Angelica Ehara, de Oliveira Karen Brajão
Abstract excerpt
The main purpose was to assess the effect of c.29C>T and c.74G>C polymorphisms in the TGFB1 signal peptide on HPV infection and development of cervical lesions. Cervical swabs and blood samples were obtained from 349 outpatient women, along with socio-demographic and sexual behavioral data. The study population was stratified by absence or presence of HPV DNA, as tested by PCR, as well as by lesion grade. TGFB1...
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