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Role of microRNA in hydroxyurea mediated HbF induction in sickle cell anaemia patients

7 Jan 2023

Abstract excerpt

Abstract Hydroxyurea (HU) is found to be beneficial in sickle cell anaemia (SCA) patients, due to its ability to increase foetal haemoglobin (HbF), however, patients show a variable response. Differences in HbF levels are attributed to many factors; but, the role of miRNA in HbF regulation is sparsely investigated. In this study, we evaluated the effect of miRNA expression on HbF induction in relation to...

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PMID: 36611033
DOI: 10.1038/s41598-022-25444-3

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