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A systematic review of known mechanisms of hydroxyurea-induced fetal hemoglobin for treatment of sickle cell disease.

Expert review of hematology - 1 Oct 2015

Pule Gift D, Mowla Shaheen, Novitzky Nicolas, Wiysonge Charles S, Wonkam Ambroise

Abstract excerpt

AIM: To report on molecular mechanisms of fetal hemoglobin (HbF) induction by hydroxyurea (HU) for the treatment of sickle cell disease. STUDY DESIGN: Systematic review. RESULTS: Studies have provided consistent associations between genomic variations in HbF-promoting loci and variable HbF level in response to HU. Numerous signal transduction pathways have been implicated, through the identification of key...

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Anemia, Sickle Cell
Cyclic AMP
Cyclic GMP
Fetal Hemoglobin
gamma-Globins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pharmacogenetics

RNA Processing, Post-Transcriptional

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Identifiers

PMID: 26327494
DOI: 10.1586/17474086.2015.1078235
PMCID: PMC4829639

Genes

BCL11A
HBS1L
MYB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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