Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA Expression in β-Thalassemia and Sickle Cell Disease: A Role in The Induction of Fetal Hemoglobin.

1 Jan 2016

Abstract excerpt

Today the regulatory role of microRNAs (miRs) is well characterized in many diverse cel- lular processes. MiR-based regulation is categorized under epigenetic regulatory mecha- nisms. These small non-coding RNAs participate in producing and maturing erythrocytes, expressing hematopoietic factors and regulating expression of globin genes by post-tran- scriptional gene silencing. The changes in expression of miRs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Hemoglobinopathies and Related Disorders
Share to Kruppel-like factors research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26862517
DOI: 10.22074/cellj.2016.3808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA Expression in β-Thalassemia and Sickle Cell Disease: A Role in The Induction of Fetal Hemoglobin.PMID 26862517Read ↗

MicroRNAs in β-thalassemia.Semantic proximity Read ↗

Exploring epigenetic and microRNA approaches for γ-globin gene regulationSemantic proximity Read ↗

Abnormal regulation of microRNAs and related genes in pediatric β‐thalassemiaSemantic proximity Read ↗

Original Research: Stable expression of miR-34a mediates fetal hemoglobin induction in K562 cells.Semantic proximity Read ↗

Hydroxyurea-Induced miRNA Expression in Sickle Cell Disease Patients in AfricaSemantic proximity Read ↗

Hydroxyurea down‐regulates <i>BCL11A, KLF</i>‐<i>1</i> and <i>MYB</i> through miRNA‐mediated actions to induce γ‐globin expression: implications for new therapeutic approaches of sickle cell diseaseSemantic proximity Read ↗

Mir-144 selectively regulates embryonic α-hemoglobin synthesis during primitive erythropoiesisSemantic proximity Read ↗

Role of microRNA in hydroxyurea mediated HbF induction in sickle cell anaemia patientsSemantic proximity Read ↗

Targeting Genetic Modifiers of HBG Gene Expression in Sickle Cell Disease: The miRNA OptionSemantic proximity Read ↗

Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies.Semantic proximity Read ↗

miR-30a regulates γ-globin expression in erythoid precursors of intermedia thalassemia through targeting BCL11ASemantic proximity Read ↗

PUM1 mediates the posttranscriptional regulation of human fetal hemoglobinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.