Article
The intrinsic genetic and epigenetic regulator factors as therapeutic targets, and the effect on fetal globin gene expression.
Expert review of hematology - 1 Jan 2018
Adelvand Pegah, Hamid Mohammed, Sardari Soroush
Abstract excerpt
INTRODUCTION: The effort to induce fetal globin or Hb F gene expression as an alternative therapy for blood transfusion has been ongoing for few decades, with promising results evident in patients with hemoglobinopathies. Although the clinical outcomes have been satisfactory and significant, there are still concerns about the safety of Hb F inducers in the long-term. There are potent inducers which lose their...
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