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Article

Hydroxyurea-Induced miRNA Expression in Sickle Cell Disease Patients in Africa

28 May 2019

Abstract excerpt

Hydroxyurea (HU) is clinically beneficial in Sickle Cell Disease (SCD) through foetal haemoglobin (HbF) induction; however, the mechanism of HU is not yet fully elucidated. Selected miRNAs have been associated with HU-induced HbF production. We have investigated differential HU-induced global miRNA expression in peripheral blood of adult SCD patients in patients from Congo, living in South Africa. We found 22 of...

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PMID: 31231425
DOI: 10.3389/fgene.2019.00509

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