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Article

MIR 29B mediates epigenetic mechanisms of HBG gene activation

19 Mar 2019

Abstract excerpt

Sickle cell disease (SCD) affects over 2 million people worldwide with high morbidity and mortality in underdeveloped countries. Therapeutic interventions aimed at reactivating fetal haemoglobin (HbF) is an effective approach for improving survival and ameliorating the clinical severity of SCD. A class of agents that inhibit DNA methyltransferase (DNMT) activity show promise as HbF inducers because off-target...

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Share to Epigenetics and DNA Methylation
Share to Hemoglobinopathies and Related Disorders

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 30891745
DOI: 10.1111/bjh.15870

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