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Article

Probabilistic integration of transcriptome-wide association studies and colocalization analysis identifies key molecular pathways of complex traits.

American journal of human genetics - 5 Jan 2023

Okamoto Jeffrey, Wang Lijia, Yin Xianyong, Luca Francesca, Pique-Regi Roger, Helms Adam, Im Hae Kyung, Morrison Jean, Wen Xiaoquan

Abstract excerpt

Integrative genetic association methods have shown great promise in post-GWAS (genome-wide association study) analyses, in which one of the most challenging tasks is identifying putative causal genes and uncovering molecular mechanisms of complex traits. Recent studies suggest that prevailing computational approaches, including transcriptome-wide association studies (TWASs) and colocalization analysis, are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36608684
DOI: 10.1016/j.ajhg.2022.12.002
PMCID: PMC9892769

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