Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype.

doi:10.1172/jci.insight.156049

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Article

Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype.

JCI insight - 8 Feb 2023

Vieira Vinicius, Lim Nicholas, Singh Alveera, Leitman Ellen, Dsouza Reena, Adland Emily, Muenchhoff Maximilian, Roider Julia, Marin Lopez Miguel, Carabelli Julieta, Giandhari Jennifer, Groll Andreas, Jooste Pieter, Prado Julia G, Thobakgale Christina, Dong Krista, Kiepiela Photini, Prendergast Andrew J, Tudor-Williams Gareth, Frater John, Walker Bruce D, Ndung'u Thumbi, Ramsuran Veron, Leslie Alasdair, Kløverpris Henrik N, Goulder Philip

Abstract excerpt

HIV nonprogression despite persistent viremia is rare among adults who are naive to antiretroviral therapy (ART) but relatively common among ART-naive children. Previous studies indicate that ART-naive pediatric slow progressors (PSPs) adopt immune evasion strategies similar to those described in natural hosts of SIV. However, the mechanisms underlying this immunophenotype are not well understood. In a cohort of...

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Identifiers

PMID: 36602861
DOI: 10.1172/jci.insight.156049
PMCID: PMC9977437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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