Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of HIV-specific CD8+ T cells in pediatric HIV cure strategies after widespread early viral escape

5 Oct 2017

Abstract excerpt

Recent studies have suggested greater HIV cure potential among infected children than adults. A major obstacle to HIV eradication in adults is that the viral reservoir is largely comprised of HIV-specific cytotoxic T lymphocyte (CTL) escape variants. We here evaluate the potential for CTL in HIV-infected slow-progressor children to play an effective role in "shock-and-kill" cure strategies. Two distinct subgroups...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS Research and Interventions
Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28983013
DOI: 10.1084/jem.20162123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of HIV-specific CD8+ T cells in pediatric HIV cure strategies after widespread early viral escapePMID 28983013Read ↗

Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child.Semantic proximity Read ↗

Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype.Semantic proximity Read ↗

HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.Semantic proximity Read ↗

Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

Diverse Impacts of HIV Latency-Reversing Agents on CD8+ T-Cell Function: Implications for HIV CureSemantic proximity Read ↗

Escape mutations in HIV infection and its impact on CD8+ T cell responses.Semantic proximity Read ↗

Immunology of pediatric HIV infectionSemantic proximity Read ↗

Early Emergence and Long-Term Persistence of HIV-Infected T-Cell Clones in ChildrenSemantic proximity Read ↗

Higher HIV-1 evolutionary rate is associated with cytotoxic T lymphocyte escape mutations in infants.Semantic proximity Read ↗

Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV InfectionSemantic proximity Read ↗

Transient T cell receptor beta-chain variable region-specific expansions of CD4+ and CD8+ T cells during the early phase of pediatric human immunodeficiency virus infection: characterization of expanded cell populations by T cell receptor phenotyping.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.