Article
Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of life.
Clinical immunology (Orlando, Fla.) - 1 Mar 2009
Mansoor Nazma, Abel Brian, Scriba Thomas J, Hughes Jane, de Kock Marwou, Tameris Michele, Mlenjeni Sylvia, Denation Lea, Little Francesca, Gelderbloem Sebastian, Hawkridge Anthony, Boom W Henry, Kaplan Gilla, Hussey Gregory D, Hanekom Willem A
Abstract excerpt
HIV-1 infection causes a severe T cell compromise; however, little is known about changes in naive, memory, effector and senescent T cell subsets during the first year of life. T cell subsets were studied over the first year of life in blood from 3 infant cohorts: untreated HIV-infected, HIV-exposed but uninfected, and HIV-unexposed. In HIV-infected infants, the frequency of CCR7(+)CD45RA(+) naive CD8(+) T cells...
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