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Accelerated CD8+ T cell maturation in infants with perinatal HIV infection

10 Apr 2024

Abstract excerpt

In perinatal HIV infection, early antiretroviral therapy (ART) initiation is recommended but questions remain regarding infant immune responses to HIV and its impact on immune development. Using single cell transcriptional and phenotypic analysis we evaluated the T cell compartment at pre-ART initiation of infants with perinatally acquired HIV from Maputo, Mozambique (Towards AIDS Remission Approaches cohort)....

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PMID: 38706858
DOI: 10.1016/j.isci.2024.109720

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