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SARS-CoV-2 Error Catastrophe Under Molnupiravir: Mutagenic Enhancement Enables Viral Persistence with Impaired Fitness.

Viruses - 23 Feb 2026

Tomita Yuriko, Miyazaki Kaya, Mochizuki Rika, Hasegawa Hideki

Abstract excerpt

Molnupiravir induces mutations that render severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication-competent through error catastrophe mechanisms. Previous studies showed no resistant virus emergence during prolonged molnupiravir treatment, with no resistant variants reported. However, these approaches were limited by genetic uniformity at passage initiation. To investigate viral population...

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PMID: 41754616
DOI: 10.3390/v18020273
PMCID: PMC12945248

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