Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Murine norovirus (MNV-1) exposure in vitro to the purine nucleoside analog Ribavirin increases quasispecies diversity.

Virus research - 4 Jan 2016

Julian Timothy R, Baugher Joseph D, Rippinger Christine M, Pinekenstein Rebecca, Kolawole Abimbola O, Mehoke Thomas S, Wobus Christiane E, Feldman Andrew B, Pineda Fernando J, Schwab Kellogg J

Abstract excerpt

Ribavirin is a pharmaceutical antiviral used for the treatment of RNA virus infections including norovirus, hepatitis C virus, hepatitis E virus, Lassa virus, respiratory syncytial virus, and rhinovirus. Despite the drug's history and documented efficacy, the antiviral mechanism of Ribavirin remains unclear. Mechanisms proposed include depletion of the intracellular GTP pool, immunomodulatory effects, induction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Cell Line

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Mutation

Share to Norovirus

Share to Ribavirin

Source

Identifiers

PMID: 26494169
DOI: 10.1016/j.virusres.2015.10.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Murine norovirus (MNV-1) exposure in vitro to the purine nucleoside analog Ribavirin increases quasispecies diversity.PMID 26494169Read ↗

Implications of high RNA virus mutation rates: lethal mutagenesis and the antiviral drug ribavirin.Semantic proximity Read ↗

High-throughput sequencing analysis reveals the genetic diversity of different regions of the murine norovirus genome during in vitro replication.Semantic proximity Read ↗

Mechanisms of action of ribavirin against distinct viruses.Semantic proximity Read ↗

Atypical Mutational Spectrum of SARS-CoV-2 Replicating in the Presence of Ribavirin.Semantic proximity Read ↗

In-Host HEV Quasispecies Evolution Shows the Limits of Mutagenic Antiviral TreatmentsSemantic proximity Read ↗

RNA virus error catastrophe: direct molecular test by using ribavirin.Semantic proximity Read ↗

Targeting viral genome synthesis as broad-spectrum approach against RNA virus infectionsSemantic proximity Read ↗

Advances Toward a Norovirus Antiviral: From Classical Inhibitors to Lethal MutagenesisSemantic proximity Read ↗

SARS-CoV-2 Error Catastrophe Under Molnupiravir: Mutagenic Enhancement Enables Viral Persistence with Impaired Fitness.Semantic proximity Read ↗

Generation and characterization of influenza A viruses with altered polymerase fidelity.Semantic proximity Read ↗

Influence of genome-scale RNA structure disruption on the replication of murine norovirus--similar replication kinetics in cell culture but attenuation of viral fitness in vivo.Semantic proximity Read ↗

Influence of Ribavirin on Mumps Virus Population Diversity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.