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The mutational landscape of SARS-CoV-2 provides new insight into viral evolution and fitness

11 Jul 2025

Abstract excerpt

Although vaccines and treatments have strengthened our ability to combat the COVID-19 pandemic, new variants of SARS-CoV-2 continue to emerge in human populations. Because the evolution of SARS-CoV-2 is driven by mutation, a better understanding of its mutation rate and spectrum could improve our ability to forecast the trajectory of the pandemic. Here, we use circular RNA consensus sequencing (CirSeq) to...

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PMID: 40645940
DOI: 10.1038/s41467-025-61555-x

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