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B cell analyses after SARS-CoV-2 mRNA third vaccination reveals a hybrid immunity like antibody response

4 Jan 2023

Abstract excerpt

The continuous evolution of SARS-CoV-2 generated highly mutated variants able to escape natural and vaccine-induced primary immunity. The administration of a third mRNA vaccine dose induces a secondary response with increased protection. Here we investigate the longitudinal evolution of the neutralizing antibody response in four donors after three mRNA doses at single-cell level. We sorted 4100 spike protein...

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PMID: 36599850
DOI: 10.1038/s41467-022-35781-6

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