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Article

Early human B cell signatures of the primary antibody response to mRNA vaccination

27 Jun 2022

Abstract excerpt

Messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are highly effective at inducing protective immunity. However, weak antibody responses are seen in some individuals, and cellular correlates of immunity remain poorly defined, especially for B cells. Here we used unbiased approaches to longitudinally dissect primary antibody, plasmablast, and memory B cell (MBC)...

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PMID: 35759653
DOI: 10.1073/pnas.2204607119

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