Spike recognition and neutralization of SARS-CoV-2 Omicron subvariants elicited after the third dose of mRNA vaccine.

doi:10.1016/j.celrep.2023.111998

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Article

Spike recognition and neutralization of SARS-CoV-2 Omicron subvariants elicited after the third dose of mRNA vaccine.

Cell reports - 31 Jan 2023

Tauzin Alexandra, Nicolas Alexandre, Ding Shilei, Benlarbi Mehdi, Medjahed Halima, Chatterjee Debashree, Dionne Katrina, Gong Shang Yu, Gendron-Lepage Gabrielle, Bo Yuxia, Perreault Josée, Goyette Guillaume, Gokool Laurie, Arlotto Pascale, Morrisseau Chantal, Tremblay Cécile, Martel-Laferrière Valérie, De Serres Gaston, Levade Inès, Kaufmann Daniel E, Côté Marceline, Bazin Renée, Finzi Andrés

Abstract excerpt

Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants have recently emerged, becoming the dominant circulating strains in many countries. These variants contain a large number of mutations in their spike glycoprotein, raising concerns about vaccine efficacy. In this study, we evaluate the ability of plasma from a cohort of individuals that received three doses of mRNA vaccine to...

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Identifiers

PMID: 36656710
DOI: 10.1016/j.celrep.2023.111998
PMCID: PMC9826988

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