Article
PIK3CA and PIK3R1 tumor mutational landscape in a pan-cancer patient cohort and its association with pathway activation and treatment efficacy.
Scientific reports - 18 Mar 2023
Tharin Zoé, Richard Corentin, Derangère Valentin, Ilie Alis, Arnould Laurent, Ghiringhelli François, Boidot Romain, Ladoire Sylvain
Abstract excerpt
There is little data concerning the implications of PIK3CA mutations outside of the known hotspots described in ER+/HER2- metastatic breast cancer (mBC). Similarly, PIK3R1 mutations could also lead to activation of PI3K pathway, but are poorly described. We determined the incidence and type of all somatic PIK3CA and PIK3R1 mutations by whole exome sequencing (WES) in a pan-cancer cohort of 1200 patients....
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