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Article

Molecular dynamic simulation and functional analysis of pathogenic PTEN mutations in glioblastoma.

Journal of biomolecular structure & dynamics - 1 Jan 2023

Cetintas Vildan Bozok, Duzgun Zekeriya, Akalin Taner, Ozgiray Erkin, Dogan Eda, Yildirim Zafer, Akinturk Nevhis, Biceroglu Huseyin, Ertan Yesim, Kosova Buket

Abstract excerpt

PTEN, a dual-phosphatase and scaffold protein, is one of the most commonly mutated tumour suppressor gene across various cancer types in human. The aim of this study therefore was to investigate the stability, structural and functional effects, and pathogenicity of 12 missense PTEN mutations (R15S, E18G, G36R, N49I, Y68H, I101T, C105F, D109N, V133I, C136Y, R173C and N276S) found by next generation sequencing of...

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Identifiers

PMID: 36591942
DOI: 10.1080/07391102.2022.2162582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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