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Article

Elucidating PTEN conformational dynamics and phosphatase regulation via integrative modeling and mutation prediction.

Structure (London, England : 1993) - 4 Sept 2025

Dawson Jennifer Erin, Smith Iris Nira, Tushar Ann Marie, Eng Charis

Abstract excerpt

PTEN (Phosphatase and TENsin homolog deleted on chromosome ten) is a major tumor suppressor gene that is frequently mutated or lost under cancerous conditions. PTEN is a dual-specificity phosphatase that negatively regulates the PI3K/AKT/mTOR signaling pathway at the plasma membrane (PM). Its functional regulation and cellular localization are known to be conformationally driven. Access to the PM is...

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Source

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Identifiers

PMID: 40614725
DOI: 10.1016/j.str.2025.06.002
PMCID: PMC12233165

Genes

PTEN
C2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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