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Article

Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer.

Proteins - 1 Nov 2016

Smith Iris N, Briggs James M

Abstract excerpt

The phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene encodes a tumor suppressor phosphatase that has recently been found to be frequently mutated in patients with endometriosis, endometrial cancer and ovarian cancer. Here, we present the first computational analysis of 13 somatic missense PTEN mutations associated with these phenotypes. We found that a majority of the mutations are associated...

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Identifiers

PMID: 27481051
DOI: 10.1002/prot.25105
PMCID: PMC5073044

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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