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Article

Molecular dynamic study on PTEN frameshift mutations in breast cancer provide c2 domain as a potential biomarker.

Journal of biomolecular structure & dynamics - 1 Apr 2022

Karn Rohit, Emerson Isaac Arnold

Abstract excerpt

PTEN is a tumour suppressor gene known for regulating apoptosis, cell growth, and many other pathways. It is one of the most frequently mutated genes comprising the phosphatase domain (PD) and C terminal domain (C2). Direct therapeutic methods are not applicable for targeting PTEN because once gets mutated, it needs restoration. For mutant detection and restoration using PTEN mRNA there is a need to explore...

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Source

Identifiers

PMID: 33183179
DOI: 10.1080/07391102.2020.1845802

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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