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Article

A new insight into structural and functional impact of single-nucleotide polymorphisms in PTEN gene.

Cell biochemistry and biophysics - 1 Jun 2013

George Priya Doss C, Rajith B

Abstract excerpt

Phosphatase and tensin homolog (PTEN) plays essential roles in cellular processes including survival, proliferation, energy metabolism, and cellular architecture. Activating the mutations of PTEN has long been known to produce a variety of disorders, mainly diabetes and cancer in humans. Owing to the importance of PTEN gene, a functional analysis using different in silico approaches was undertaken to explore the...

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Source

Identifiers

PMID: 23161105
DOI: 10.1007/s12013-012-9472-9

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A new insight into structural and functional impact of single-nucleotide polymorphisms in PTEN gene.PMID 23161105Read ↗

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PTENpred: A Designer Protein Impact Predictor for PTEN-related Disorders.Semantic proximity Read ↗

Classifying disease-associated variants using measures of protein activity and stabilitySemantic proximity Read ↗

Investigation of deleterious effects of nsSNPs in the POT1 gene: a structural genomics‐based approach to understand the mechanism of cancer developmentSemantic proximity Read ↗

The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene.Semantic proximity Read ↗

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