Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting of cancer neoantigens with donor-derived T cell receptor repertoires.

Science (New York, N.Y.) - 10 Jun 2016

Strønen Erlend, Toebes Mireille, Kelderman Sander, van Buuren Marit M, Yang Weiwen, van Rooij Nienke, Donia Marco, Böschen Maxi-Lu, Lund-Johansen Fridtjof, Olweus Johanna, Schumacher Ton N

Abstract excerpt

Accumulating evidence suggests that clinically efficacious cancer immunotherapies are driven by T cell reactivity against DNA mutation-derived neoantigens. However, among the large number of predicted neoantigens, only a minority is recognized by autologous patient T cells, and strategies to broaden neoantigen-specific T cell responses are therefore attractive. We found that naïve T cell repertoires of healthy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Neoplasm
Share to Blood Donors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to HLA-A2 Antigen

Share to Immunotherapy

Share to Lymphocytes, Tumor-Infiltrating

Share to Primary Cell Culture

Share to Receptors, Antigen, T-Cell

Source

Identifiers

PMID: 27198675
DOI: 10.1126/science.aaf2288

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting of cancer neoantigens with donor-derived T cell receptor repertoires.PMID 27198675Read ↗

Neoantigen-targeted CD8+ T cell responses with PD-1 blockade therapy.Semantic proximity Read ↗

Identification of patient-specific CD4+ and CD8+ T cell neoantigens through HLA-unbiased genetic screens.Semantic proximity Read ↗

Advances in identification and selection of personalized neoantigen/T-cell pairs for autologous adoptive T cell therapiesSemantic proximity Read ↗

Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cellsSemantic proximity Read ↗

Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancersSemantic proximity Read ↗

Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor.Semantic proximity Read ↗

Targeting neoantigens for cancer immunotherapy: Table 1.Semantic proximity Read ↗

Progress in Neoantigen Targeted Cancer ImmunotherapiesSemantic proximity Read ↗

Immunopharmacogenomics towards personalized cancer immunotherapy targeting neoantigens.Semantic proximity Read ↗

Characterization of CD8+ T-cell responses to non-anchor-type HLA class I neoantigens with single amino-acid substitutions.Semantic proximity Read ↗

A functional identification platform reveals frequent, spontaneous neoantigen-specific T cell responses in patients with cancerSemantic proximity Read ↗

Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCRSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.