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Selecting highly affine and well-expressed TCRs for gene therapy of melanoma

28 Jul 2007

Abstract excerpt

A recent phase 1 trial has demonstrated that the generation of tumor-reactive T lymphocytes by transfer of specific T-cell receptor (TCR) genes into autologous lymphocytes is feasible. However, compared with results obtained by infusion of tumor-infiltrating lymphocytes, the response rate observed in this first TCR gene therapy trial is low. One strategy that is likely to enhance the success rate of TCR gene...

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PMID: 17660381
DOI: 10.1182/blood-2007-02-075010

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