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Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice

29 Dec 2022

Abstract excerpt

One goal of regenerative medicine is to rejuvenate tissues and extend lifespan by restoring the function of endogenous aged stem cells. However, evidence that somatic stem cells can be targeted in vivo to extend lifespan is still lacking. Here, we demonstrate that after a short systemic treatment with a specific inhibitor of the small RhoGTPase Cdc42 (CASIN), transplanting aged hematopoietic stem cells (HSCs)...

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Share to Epigenetics and DNA Methylation
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PMID: 36581635
DOI: 10.1038/s41536-022-00275-y

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