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Article

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles.

Nature medicine - 1 Mar 2014

Cosgrove Benjamin D, Gilbert Penney M, Porpiglia Ermelinda, Mourkioti Foteini, Lee Steven P, Corbel Stephane Y, Llewellyn Michael E, Delp Scott L, Blau Helen M

Abstract excerpt

The elderly often suffer from progressive muscle weakness and regenerative failure. We demonstrate that muscle regeneration is impaired with aging owing in part to a cell-autonomous functional decline in skeletal muscle stem cells (MuSCs). Two-thirds of MuSCs from aged mice are intrinsically defective relative to MuSCs from young mice, with reduced capacity to repair myofibers and repopulate the stem cell...

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Identifiers

PMID: 24531378
DOI: 10.1038/nm.3464
PMCID: PMC3949152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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