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Loss of stem cell regenerative capacity within aged niches

19 Feb 2007

Abstract excerpt

This work uncovers novel mechanisms of aging within stem cell niches that are evolutionarily conserved between mice and humans and affect both embryonic and adult stem cells. Specifically, we have examined the effects of aged muscle and systemic niches on key molecular identifiers of regenerative potential of human embryonic stem cells (hESCs) and post-natal muscle stem cells (satellite cells). Our results reveal...

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PMID: 17381551
DOI: 10.1111/j.1474-9726.2007.00286.x

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