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Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity

14 Jan 2021

Abstract excerpt

In this study, we characterize age-related phenotypes of human hematopoietic stem cells (HSC). We report increased frequencies of HSC, hematopoietic progenitor cells and lineage negative cells in the elderly but a decreased frequency of multi-lymphoid progenitors. Aged human HSC further exhibited a delay in initiating division ex vivo though without changes in their division kinetics. The activity of the small...

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PMID: 33440922
DOI: 10.3324/haematol.2020.269670

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