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Article

In Vitro and In Vivo Models for Metastatic Intestinal Tumors Using Genotype-Defined Organoids.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023

Morita Atsuya, Nakayama Mizuho, Oshima Hiroko, Oshima Masanobu

Abstract excerpt

It has been established that the accumulation of driver gene mutations causes malignant progression of colorectal cancer (CRC) through positive selection and clonal expansion, similar to Darwin's evolution. Following this multistep tumorigenesis concept, we previously showed the specific mutation patterns for each process of malignant progression, including submucosal invasion, epithelial mesenchymal transition...

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Identifiers

PMID: 37355534
DOI: 10.1007/978-1-0716-3331-1_2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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