Article
Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.
PLoS genetics - 30 May 2008
Taylor Kimberly E, Remmers Elaine F, Lee Annette T, Ortmann Ward A, Plenge Robert M, Tian Chao, Chung Sharon A, Nititham Joanne, Hom Geoffrey, Kao Amy H, Demirci F Yesim, Kamboh M Ilyas, Petri Michelle, Manzi Susan, Kastner Daniel L, Seldin Michael F, Gregersen Peter K, Behrens Timothy W, Criswell Lindsey A
Abstract excerpt
Systemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous clinical manifestations. A polymorphism in the STAT4 gene has recently been established as a risk factor for SLE, but the relationship with specific SLE subphenotypes has not been studied. We studied 137 SNPs in the STAT4 region genotyped in 4 independent SLE case series (total n = 1398) and 2560 healthy controls, along with...
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