Association of the STAT4 Gene rs7574865 Polymorphism with IFN-γ Levels in Patients with Systemic Lupus Erythematosus.

doi:10.3390/genes14030537

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Association of the STAT4 Gene rs7574865 Polymorphism with IFN-γ Levels in Patients with Systemic Lupus Erythematosus.

Genes - 21 Feb 2023

Esparza Guerrero Yussef, Vazquez Villegas Maria Luisa, Nava Valdivia Cesar Arturo, Ponce Guarneros Juan Manuel, Perez Guerrero Edsaul Emilio, Gomez Ramirez Eli Efrain, Ramirez Villafaña Melissa, Contreras Haro Betsabe, Martinez Hernandez Alejandra, Cardona Muñoz Ernesto German, Nuño Arana Ismael, Gallardo Moya Sergio Gabriel, Celis Alfredo, Gonzalez Lopez Laura, Gamez Nava Jorge Ivan, Saldaña Cruz Ana Miriam

Abstract excerpt

STAT4 plays an important role in disease activity in SLE patients. STAT4 particles have the capacity to activate the transcription of genes associated with the production of TH1 and Th17 lymphocytes, with a greater predominance on the production of IFN-γ and IL-17A. The presence of variants in STAT4 genes has a major impact on the generation of autoimmunity. However, there are few studies evaluating the impact of...

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PMID: 36980810
DOI: 10.3390/genes14030537
PMCID: PMC10048585

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