Article
The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE.
Annals of the rheumatic diseases - 1 Jul 2018
Hagberg Niklas, Joelsson Martin, Leonard Dag, Reid Sarah, Eloranta Maija-Leena, Mo John, Nilsson Magnus K, Syvänen Ann-Christine, Bryceson Yenan T, Rönnblom Lars
Abstract excerpt
OBJECTIVES: Genetic variants in the transcription factor STAT4 are associated with increased susceptibility to systemic lupus erythematosus (SLE) and a more severe disease phenotype. This study aimed to clarify how the SLE-associated intronic STAT4 risk allele rs7574865[T] affects the function of immune cells in SLE. METHODS: Peripheral blood mononuclear cells (PBMCs) were isolated from 52 genotyped patients with...
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