Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies

12 Dec 2022

Abstract excerpt

The human immunoglobulin heavy-chain (IGH) locus is exceptionally polymorphic, with high levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which may influence responses to infection and vaccination. For an improved understanding of inter-individual differences in antibody responses, we isolated SARS-CoV-2 spike-specific monoclonal antibodies from convalescent health care...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Phagocytosis and Immune Regulation
Share to SARS-CoV-2 and COVID-19 Research
Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36574772
DOI: 10.1016/j.immuni.2022.12.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodiesPMID 36574772Read ↗

Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responsesSemantic proximity Read ↗

An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape.Semantic proximity Read ↗

Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variantsSemantic proximity Read ↗

Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategiesSemantic proximity Read ↗

Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2Semantic proximity Read ↗

IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity.Semantic proximity Read ↗

Immunoglobulin germline gene variation and its impact on human disease.Semantic proximity Read ↗

Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patientsSemantic proximity Read ↗

The prominent role of a CDR1 somatic hypermutation for convergent IGHV3-53/3-66 antibodies in binding to SARS-CoV-2Semantic proximity Read ↗

Genetic determinants of IgG antibody response to COVID-19 vaccinationSemantic proximity Read ↗

An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms.Semantic proximity Read ↗

Genetically diverse influenza antibodies highlight the role of IG germline gene variation and inform population-comprehensive vaccine strategies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.