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Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses

1 Mar 2023

Abstract excerpt

The antibody response to SARS-CoV-2 shows biased immunoglobulin heavy chain variable (IGHV) gene usage, allowing definition of genetic signatures for some classes of neutralizing antibodies. We investigated IGHV gene usage frequencies by sorting spike-specific single memory B cells from individuals infected with SARS-CoV-2 early in the pandemic. From two study participants and 703 spikespecific B cells, the most...

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PMID: 37041983
DOI: 10.3389/fviro.2023.1128253

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