Article
Leveraging pleiotropy to discover and interpret GWAS results for sleep-associated traits.
PLoS genetics - 1 Dec 2022
Chun Sung, Akle Sebastian, Teodosiadis Athanasios, Cade Brian E, Wang Heming, Sofer Tamar, Evans Daniel S, Stone Katie L, Gharib Sina A, Mukherjee Sutapa, Palmer Lyle J, Hillman David, Rotter Jerome I, Hanis Craig L, Stamatoyannopoulos John A, Redline Susan, Cotsapas Chris, Sunyaev Shamil R
Abstract excerpt
Genetic association studies of many heritable traits resulting from physiological testing often have modest sample sizes due to the cost and burden of the required phenotyping. This reduces statistical power and limits discovery of multiple genetic associations. We present a strategy to leverage pleiotropy between traits to both discover new loci and to provide mechanistic hypotheses of the underlying...
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