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Article

Shared genetic architecture between sleep traits and cardiometabolic diseases.

EBioMedicine - 1 Apr 2026

Zhang Yuan, Jian Shijie, Ouyang Haiyan, Purushotham Yogesh, Yu Qiao, Tang Beisha, Gottlieb Daniel J, Sofer Tamar, Yi Minhan

Abstract excerpt

BACKGROUND: Sleep traits, including sleep apnoea (SA), insomnia, daytime sleepiness, and snoring, frequently co-occur with cardiometabolic diseases (CMDs), with shared genetic factors suspected to underlie these associations. However, the contribution of shared genetic determinants to these associations is not fully understood. METHODS: We conducted a genome-wide pleiotropic association study applying sequential...

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Identifiers

PMID: 41833577
DOI: 10.1016/j.ebiom.2026.106220
PMCID: PMC12999290

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APOE
MVP

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