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Article

Shared genetic architecture between sleep traits and cardiometabolic diseases.

EBioMedicine - 1 Apr 2026

Zhang Yuan, Jian Shijie, Ouyang Haiyan, Purushotham Yogesh, Yu Qiao, Tang Beisha, Gottlieb Daniel J, Sofer Tamar, Yi Minhan

Abstract excerpt

BACKGROUND: Sleep traits, including sleep apnoea (SA), insomnia, daytime sleepiness, and snoring, frequently co-occur with cardiometabolic diseases (CMDs), with shared genetic factors suspected to underlie these associations. However, the contribution of shared genetic determinants to these associations is not fully understood. METHODS: We conducted a genome-wide pleiotropic association study applying sequential...

Topics

Humans
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Genetic Predisposition to Disease
Cardiovascular Diseases
Genetic Pleiotropy
Phenotype
Metabolic Diseases
Sleep
Sleep Apnea Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41833577
DOI: 10.1016/j.ebiom.2026.106220
PMCID: PMC12999290

Genes

APOE
MVP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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