Article
Cortical GABA markers identify a molecular subtype of psychotic and bipolar disorders.
Psychological medicine - 1 Sept 2016
Volk D W, Sampson A R, Zhang Y, Edelson J R, Lewis D A
Abstract excerpt
BACKGROUND: Deficits in gamma aminobutyric acid (GABA) neuron-related markers, including the GABA-synthesizing enzyme GAD67, the calcium-binding protein parvalbumin, the neuropeptide somatostatin, and the transcription factor Lhx6, are most pronounced in a subset of schizophrenia subjects identified as having a 'low GABA marker' (LGM) molecular phenotype. Furthermore, schizophrenia shares degrees of genetic...
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