Article
Single-cell transcriptional profiling uncovers the association between EOMES+CD8+ T cells and acquired EGFR-TKI resistance.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Jan 2023
Wang Guosheng, Sun Jiaxing, Zhang Jing, Zhu Qiping, Lu Jingjing, Gao Shaoyong, Wang Feilong, Yin Qi, Wan Yuan, Li Qiang
Abstract excerpt
Acquired resistance to tyrosine kinase inhibitors (TKIs) is reportedly inevitable in lung cancers harboring epidermal growth factor receptor (EGFR) mutations, emphasizing the need for novel approaches to predict EGFR-TKI resistance for clinical monitoring and patient management. This study identified a significant increase in eomesodermin (EOMES)+CD8+ T cells in the TKI-resistant patients, which was correlated...
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