Article

An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKI resistant cells by modulating miR-335 expression

2021-01-07

Abstract excerpt

<h4>ABSTRACT</h4> Lung cancer remains the leading cause of cancer-related mortality worldwide, despite current advancements in research and therapeutics. Many patients diagnosed with lung cancer will develop resistance to chemotherapeutic agents. In the context of non-small cell lung cancers (NSCLC) harboring EGFR oncogenic mutations, augmented levels of AXL and GAS6 have been found to drive Erlotinib resistance...

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Literature Corpus work: 35930caf-279e-52ec-a0ef-12cf635b9331
DOI: 10.1101/2021.01.06.425631

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