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Article

An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression.

eLife - 13 Jul 2021

Safaric Tepes Polona, Pal Debjani, Lindsted Trine, Ibarra Ingrid, Lujambio Amaia, Jimenez Sabinina Vilma, Senturk Serif, Miller Madison, Korimerla Navya, Huang Jiahao, Glassman Lawrence, Lee Paul, Zeltsman David, Hyman Kevin, Esposito Michael, Hannon Gregory J, Sordella Raffaella

Abstract excerpt

Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to the resistance that patients develop against chemotherapeutic agents over the course of treatment. In the context of non-small cell lung cancers (NSCLC) harboring EGFR-oncogenic mutations, augmented levels of AXL and GAS6 have been found to drive resistance...

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Identifiers

PMID: 34254585
DOI: 10.7554/eLife.66109
PMCID: PMC8285107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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