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Article

Nodal regulates trophoblast differentiation and placental development.

Developmental biology - 1 Aug 2001

Ma G T, Soloveva V, Tzeng S J, Lowe L A, Pfendler K C, Iannaccone P M, Kuehn M R, Linzer D I

Abstract excerpt

Nodal has been thought to be an embryo-specific factor that regulates development, but nodal is also expressed in the mouse placenta beginning at midgestation, specifically in the spongiotrophoblasts. In an insertional null nodal mutant, not only is embryonic development disrupted, but mouse placental development is also grossly altered with the loss of the diploid spongiotrophoblasts and labyrinth and an...

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Source

Identifiers

PMID: 11456449
DOI: 10.1006/dbio.2001.0334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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