Article

S373P Mutation Stabilizes the Receptor-binding Domain of Spike Protein in Omicron and Promotes Binding

2022-06-23

Abstract excerpt

A cluster of several newly occurring mutations on Omicron are found at the β-core region of spike protein’s receptor-binding domain (RBD), where mutation rarely happened before. Notably, the binding of SARS-CoV-2 to human receptor ACE2 via RBD happens in a dynamic airway environment, where mechanical force caused by coughing or sneezing occurs and applies to the proteins. Thus, we used atomic force microscopy-base...

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Literature Corpus work: 2aa083a8-2972-504a-a90c-14c491844494
DOI: 10.1101/2022.06.22.497114

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