Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interfacial subregions of SARS-CoV-2 spike RBD to hACE2 affect intermolecular affinity by their distinct roles played in association and dissociation kinetics.

Communications biology - 5 Dec 2024

Tang Xiangwu, Chen Jingxian, Zhang Lu, Liu Tao, Ding Min, Zheng Yun-Wen, Zhang Yinghui

Abstract excerpt

SARS-CoV-2's rapid global transmission depends on spike RBD's strong affinity to hACE2. In the context of binding hot spots well defined, the work investigated how interfacial subregions of SARS-CoV-2 spike RBD to hACE2 affect intermolecular affinity and their potential distinct roles involved in association and dissociation kinetics due to their local structural characteristics. Three spatially consecutive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin-Converting Enzyme 2
Share to Binding Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COVID-19

Share to Kinetics

Share to Protein Binding

Share to Protein Domains

Share to SARS-CoV-2

Share to Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 39638851
DOI: 10.1038/s42003-024-07081-w
PMCID: PMC11621773

Genes

SPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interfacial subregions of SARS-CoV-2 spike RBD to hACE2 affect intermolecular affinity by their distinct roles played in association and dissociation kinetics.PMID 39638851Read ↗

Molecular Dynamics Simulations Studies On The Effects Of Mutations On The Binding Affinities Between SARS-CoV-2 Spike RBD And Human ACE2Semantic proximity Read ↗

Deciphering the Impact of Mutations on the Binding Efficacy of SARS-CoV-2 Omicron and Delta Variants With Human ACE2 ReceptorSemantic proximity Read ↗

Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interaction.Semantic proximity Read ↗

Correlating the differences in the receptor binding domain of SARS-CoV-2 spike variants on their interactions with human ACE2 receptorSemantic proximity Read ↗

Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2Semantic proximity Read ↗

In silico analysis of SARS-CoV-2 spike protein N501Y and N501T mutation effects on human ACE2 binding.Semantic proximity Read ↗

E484K and N501Y SARS-CoV 2 spike mutants Increase ACE2 recognition but reduce affinity for neutralizing antibody.Semantic proximity Read ↗

Subtle Changes at the RBD/hACE2 Interface During SARS-CoV-2 Variant Evolution: A Molecular Dynamics Study.Semantic proximity Read ↗

Mechanistic Insights into the Effects of Key Mutations on SARS-CoV-2 RBD-ACE2 BindingSemantic proximity Read ↗

Mechanistic insights into the effects of key mutations on SARS-CoV-2 RBD-ACE2 binding.Semantic proximity Read ↗

Mutational landscape and <i>in silico</i> structure models of SARS-CoV-2 Spike Receptor Binding Domain reveal key molecular determinants for virus-host interactionSemantic proximity Read ↗

Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern: A Perspective for Emerging more Transmissible and Vaccine-Resistant StrainsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.